20Med Nanoparticles for delivery of oligonucleotides
Originally developed for the intracellular delivery of siRNA, 20Med Nanoparticles are widely applicable for the delivery of oligonucleotides. The bioresponsive polymeric nanoparticles can be loaded with oligonucleotides ranging from large plasmid DNAs (>12Kb) to small antisense oligos. Efficient transfection has been shown for the different payloads in a large number of cell lines. In-vivo experiments have confirmed that 20Med Nanoparticles are the preferred non-viral carrier for oligonucleotide based therapeutics, independent of the route of administration.
20Med's internal research is focused on the development of RNA based therapeutics and vaccines. 20Med Nanoparticles' efficient cell entry and rapid release of the mRNA into the cytosol provide a superior solution for delivery of the fragile payload. The ability to safely, and cost effectively, deliver any mRNA coding for a therapeutic protein or antigen opens up the way for mRNA therapeutics to deliver on its potential to become the next-generation therapeutics.